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PC (Steam): of April 21, 2017, there are 20 coronaviruses and subtypes of coronaviruses that have been identified in animals, such as rodents and birds. Recent outbreaks of a disease closely resembling SARS in humans, called Middle East Respiratory Syndrome, have appeared in the Middle East and neighboring areas. Among the 20 known coronaviruses, 11 are believed to cause significant diseases in humans, and 6 have been identified as causing human diseases, including HCoV-OC43, HCoV-HKU1, HCoV-NL63, HCoV-229E, HCoV-HKU2, and HCoV-EMC, which are classified in Group 2 (alpha coronaviruses), Group 3 (beta coronaviruses), and Group 4 (gamma coronaviruses), respectively.
These viruses contain positive-stranded RNA genomes of approximately 27 to 31 kilobases. The viral genomes contain a characteristic set of genes encoding the replicase, and structural proteins, and gene order is highly conserved among members of these groups. These viral RNA genomes are about 30% the size of those of the largest known RNA virus, the hepatitis C virus (HCV).
HCoV-OC43 was originally discovered in 1967 in the respiratory tract of healthy children in the Netherlands. It is now believed to be present in the respiratory tract of almost all adults. As its name suggests, HCoV-OC43 primarily infects the respiratory tract and is the leading cause of croup in children, accounting for an estimated 15% to 30% of cases. A second major manifestation of HCoV-OC43 is lower respiratory tract infection (LRTI), including bronchiolitis and pneumonia. Similar to other coronaviruses, it has been shown that infected patients can have difficulty clearing the virus from their respiratory tract, and thus can carry the virus for months after their primary infection. The virus has been linked to mild colds, upper respiratory tract infections, otitis media, and sinusitis in children,