Can someone please explain the "down regulation" of ACE 2 receptors that is hypothesized?
To Who it may Concerned: First and foremost, I would like to extend my sincere gratitude to the CDC and other entities on their relentless effort to develop vaccine and treatment regimen for the Covid-19 virus. Their effort will not go unnoticed as the world looked forward for a vaccine that will save countless lives. As the World comes to standstill because of the virus, there still remains many unanswered question about Covid-19 as such: What are the root causes the virus, treatment and likely mode of transmission? I would like to offer some insights about what Covid- 19 actually is. Coronavirus is the body natural reaction to harmful substances in the environment such as: radiation from the sun. The Covid-19, virus is caused by the leakage of radiation into the atmosphere from the Chernobyl reactor in Uruguay. The radiation cause spontaneous cell death which prevents the cells from regenerating thus, resulted in total organ and system failure. Life started out as: Protons, Neutrons Electrons that came together to form Atoms such: as Hydrogen, Carbon and Oxygen. Atoms – molecules; molecules -cells; cells – tissues; and two or more kinds of tissues – organ. And organs came together to performs a specialized physiologic function of the organism. The Covid-19 cause the buildup of C02, which prevents gaseous exchange of CO2 and O2 over the alveoli of the lungs and cause the lungs to fill with fluid. Thus, resulted in blood-clots that eventually leads to heart attack. The main reason why Covid-19 has a devastating effect on some people was most people lacked Iodine in their body which is produce by the Thyroid gland. The lack of iodine in the body can cause cell damage. Also, the body may lack Antioxidants. Antioxidants are substances such as: chocolate that prevents or slow damage to the cells which are cause by Free-Radicals are unstable, molecules that the body produce in reaction to harmful substances in the environment. Some treatment option for Covid-19, may include, iodine pills, fish oil, cod liver oil, and antioxidants that prevents or slow the impacts of free radicals or unstable molecules the body produce in reaction to the environment. For the mode of transmission we have to take into consideration the diffuse radiation which will explain the reason why larger group of people at a location are more susceptible to the Coronavirus. I do believe that Hyssop is one key factor that is missing in the search for the Covid-19 cure/treatment. Hyssop is a well-known medicinal, herbs that comes in oil, pills, and other forms. The herb has been used since biblical times to treat various ailments such as asthma, cold, flu, pneumonia and virus. Hyssop, has inhibitory, stimulating and antimicrobial properties that will help to relieve the dryness of the mucus at the surface lining of the stomach. The Hyssop also, aid in the removing of the obstructive phlegm from the body and which prevents the blood from becoming plasticity. Thus, will be very beneficial in the treatment of the Covid-19 virus. While I researching I became aware that the Coronavirus have capabilities that bind to the ACE-2 receptor and invade the cells. Thus, destroying the cells from inside. Hypothetically, speaking, the hyssop will act as an inhibitor that will prevent the Spike proteins from binding to the ACE-2 Receptors. Thus dislodge the binding capabilities between the molecules and prevent the virus from invading the cells. In retrospect, the Hyssop activates the T-Cells, which will help to boost the immune system.
Very good sir Now give your contact number to ask questions
Is it tru that there are very few _MRna vaccies? most of the the common cold is two at least of cornoavures along with mers,sars, and h1ni 19 isn't for 19th virus it for the year isn;t it?
This is all good information!
Thank you so much for your explanation, Doc 🙂
Kawasaki H2r disease kills more children than COVID-19.
It seems that the reality of biochemical reactions is complex, to be explained in detail in a few minutes. I am very confused. For example, this video talks about a specific sheddase as a key process
There are scientific articles talking about more than one truncated ACE2 forms, about the process of shedding or cleave catalytically active ACE2 from the cell surface into the extracellular environment.
TMPRSS2 and ADAM17 cleave ace2 differentially and only proteolysis by tmprss2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein
Very interesting and as I have been looking into this , is it fair to say that, regarding the varying amounts of ace2 receptors that different ethnicities have , can this have a bearing on levels of viral intensity seen amongst them? The uk is looking at BAME cases being 42/1000 against 6/1000 in white caucasians. I have read somewhere that levels/amounts of ace2 receptors are far higher in say Asians, north Africans etc. Could there be a link here that the media are ignoring potentially and politically? I am not a medical person by the way, just a very interested. electrician.
So Ace2 is the Death Card if you have it in spades.
The human body is amazingly made and even de engineering is very difficult !
This was designed for the ACE receptors , Wuhan did a good job in making it more deadly
I have been creating a series of posts and audio hypnotic inductions pertaining to aspects of COVID-19. My latest post and hypnotic induction focuses intention on membrane function. You can read it here: "COVID-19, Future Visions" at https://www.mindstrengthbalance.com/2020/05/06/covid-19-future-visions/. Comments welcome.
Dr. S, I take eplerenone because I have hyperaldosterone. Can you tell me if that would increase the broken off ace2 like in your diagram?
I'm taking vitamin D3, zinc, vitamin C, and Losartan for high blood pressure. I believe I am blood type O+ because my sister is. I had all flu and pneumonia shots last fall. I have CLL but have not needed treatment yet and I'm 64 year old. I work with people every day. I wear a mask and I am very cautious and use hand sanitizer and other disinfectants. I wash my clothes every day. I disinfect phones remote, knobs, counter tops, and floors frequently. What is my risk?
I had been worried about the effects of my ARB in this pandemic and found this reassuring. Thanks Doc!
Great class! Thank you!
Actually, you are wrong in this case that when Angiotensin 2(AT-II) is high, Ace-2 expression increases. No, when AT-II is high and binds to ATR-1, ACE-2 is internalized and lysed (or degraded) in the cell. So, ACE-2 expression is decreased. But when AT-II is lowered by kidneys, ACE-2 binds to its native binding partner ATR-1. Sars-cov-2 out-compete the ATR-1 for binding to ACE-2. sars-cov-2 and ATR-1 are competing with each other to bind to ACE-2 when there is no AT-II around.
So grateful for all you do!
American College of Cardiology, the American Heart Association, the Heart Failure Society of America, and the European Society of Cardiology—have issued guidelines saying patients should not stop taking the antihypertensive drugs because there’s no evidence to support the claim that they cause more-severe SARS-CoV-2 infections.
In support of that recommendation, Ankit Patel, a clinical and research fellow focusing on the kidneys at Brigham and Women’s Hospital in Boston, and his Brigham colleague Ashish Verma dug into the literature to address the confusion and reported March 24 in JAMA that there’s no definitive evidence to suggest ACE inhibitors and ARBs increase the severity of COVID-19. Another team of doctors, writing in the March 30 issue of the New England Journal of Medicine, came to the same conclusion.
Instead of making COVID-19 symptoms worse, some antihypertensive drugs may actually reduce the severity of infections, and could therefore be used to treat the disease, both sets of doctors say. A closer look at the underlying mechanisms of the medications has also buoyed another idea for how to treat COVID-19—give patients the enzyme ACE2 as a decoy to direct SARS-CoV-2 away from their cells. A biotech company developing such an approach using recombinant ACE2 received regulatory approval today (April 2) to start clinical trials on COVID-19 patients.
I believe research ha since been done in Italy and in NY where most deaths have hypertension as a comorbidity factor median age about 62…it didn’t matter if it was controlled hypertension or not and just slightly more risk for those on Ace or ARB’s. So if you have hypertension and are over 50 ..you/we need better protection!
What about Beta-Blockers like Bystolic?
In lecture 61 you also also said ace-2 receptors exist inside cell walls of veins, arteries. COV-2 binds with these receptors and causes a cascade of symptoms leading to blood clots. Watch the lecture. My question is where are all the ace-2 receptors in the body and can each receptor in every organ they inhabit be affected by the virus binding to it, if those receptors can be exposed to it as it travels through the body ?
Nice research analysis on a most current medical development. The epidemiology and the fact older ppl tend to be over"managed" by pharmacos is only aggravating a sad morbidity of pneumopathy….
I see that these medications increase ACE2, but isn't this the enzyme, and not the receptor?
Really easy!! I have been hearing both sides of the argument and the final truth is actually not difficult it's real simple. The high death rates in Hypertension and Diabetes can be separated by those who are taking ACE2 and ARBS and those who are not taking ACE@ and ARBS. Simple if 2000 people died with COVID19 that had high blood pressure similar age and males and the ARBS and ACE2 death rate was 1500 vs 500 who did not take the medication then you would have an actual number to go off of either way. this could be repeated in China, Italy etc etc
SEEMS TO ME THAT this vlog and that study are a bit backwards… HOW is it that an ARB… ACE-2 Receptor BLOCKER causes MORE ACE-2 receptor cells to form, rather thanbeing BLOCKED.?. Thus, also blocking SARS-CoV-2………………
Great Lecture. Thank you very much
awesome
So can you please answer that question. Why does the Ace-i and ARBs treatment cause ACE-2 expression? It should decrease the ACE-2 expression.
Do the ACE2 receptor and virus spike proteins tangle together like velcro loops and hooks, or are there chemical bonds? What causes the spike binding site to fold out, lower pH?
I stopped taking Lisinopril 40mg daily a week ago when I heard it could worsen the infection. I guess now I should get back on the medication?
Superbe bravo !
So.
Take ace inhibitors, get more infection. Don't take ace inhibitors, get less infection, but be more susceptible to other health issues
Perfectly engineered virus.
We also know that men are dying 30-40% more from covid than women. And we know that men have more ACE2 receptors than women.
Sounds like more than just a coincidence.
That response from the American Heart Association and others sounds a awful lot like "nothing to see here folks"..
I don't trust the integrity of any study that is essentially protecting Big Pharma and their 200 million customer base worldwide that are taking ace inhibitors.
Many sperm + 1 egg increases chances for pregnancy.
Why wouldn't many corona viruses + one cell increase chances for infection?
If I block ACE2+AT-1 by ARB …is it gonna be problem?? Bcz it's seems vasoconstriction
Thanks a lot.but where I can get ace1 …
Related https://www.youtube.com/watch?v=W1k1sUoLPlA
Can someone please explain the "down regulation" of ACE 2 receptors that is hypothesized?
To Who it may Concerned:
First and foremost, I would like to extend my sincere gratitude to the CDC and other entities on their relentless effort to develop vaccine and treatment regimen for the Covid-19 virus. Their effort will not go unnoticed as the world looked forward for a vaccine that will save countless lives. As the World comes to standstill because of the virus, there still remains many unanswered question about Covid-19 as such: What are the root causes the virus, treatment and likely mode of transmission? I would like to offer some insights about what Covid- 19 actually is.
Coronavirus is the body natural reaction to harmful substances in the environment such as: radiation from the sun. The Covid-19, virus is caused by the leakage of radiation into the atmosphere from the Chernobyl reactor in Uruguay. The radiation cause spontaneous cell death which prevents the cells from regenerating thus, resulted in total organ and system failure. Life started out as: Protons, Neutrons Electrons that came together to form Atoms such: as Hydrogen, Carbon and Oxygen. Atoms – molecules; molecules -cells; cells – tissues; and two or more kinds of tissues – organ. And organs came together to performs a specialized physiologic function of the organism.
The Covid-19 cause the buildup of C02, which prevents gaseous exchange of CO2 and O2 over the alveoli of the lungs and cause the lungs to fill with fluid. Thus, resulted in blood-clots that eventually leads to heart attack. The main reason why Covid-19 has a devastating effect on some people was most people lacked Iodine in their body which is produce by the Thyroid gland. The lack of iodine in the body can cause cell damage. Also, the body may lack Antioxidants. Antioxidants are substances such as: chocolate that prevents or slow damage to the cells which are cause by Free-Radicals are unstable, molecules that the body produce in reaction to harmful substances in the environment.
Some treatment option for Covid-19, may include, iodine pills, fish oil, cod liver oil, and antioxidants that prevents or slow the impacts of free radicals or unstable molecules the body produce in reaction to the environment. For the mode of transmission we have to take into consideration the diffuse radiation which will explain the reason why larger group of people at a location are more susceptible to the Coronavirus.
I do believe that Hyssop is one key factor that is missing in the search for the Covid-19 cure/treatment. Hyssop is a well-known medicinal, herbs that comes in oil, pills, and other forms. The herb has been used since biblical times to treat various ailments such as asthma, cold, flu, pneumonia and virus. Hyssop, has inhibitory, stimulating and antimicrobial properties that will help to relieve the dryness of the mucus at the surface lining of the stomach. The Hyssop also, aid in the removing of the obstructive phlegm from the body and which prevents the blood from becoming plasticity. Thus, will be very beneficial in the treatment of the Covid-19 virus. While I researching I became aware that the Coronavirus have capabilities that bind to the ACE-2 receptor and invade the cells. Thus, destroying the cells from inside. Hypothetically, speaking, the hyssop will act as an inhibitor that will prevent the Spike proteins from binding to the ACE-2 Receptors. Thus dislodge the binding capabilities between the molecules and prevent the virus from invading the cells. In retrospect, the Hyssop activates the T-Cells, which will help to boost the immune system.
References
Hyssopus officinalis. (n.d.). Retrieved May 19, 2020, from https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/hyssopus-officinalis
Olsen, N. (2018, May 29). Antioxidants: Health benefits and nutritional information (M. Ware, Ed.). Retrieved May 19, 2020, from https://www.medicalnewstoday.com/articles/301506
Lallanilla, M. (2019, June 20). Chernobyl: Facts About the Nuclear Disaster. Retrieved May 19, 2020, from https://www.livescience.com/39961-chernobyl.html
Letzter, R. (2019, June 04). Why Did People Take Iodine Pills After Chernobyl Exploded? Retrieved May 19, 2020, from https://www.livescience.com/65634-chernobyl-explosion-nuclear-disaster-iodine.html
Very good sir
Now give your contact number to ask questions
Is it tru that there are very few _MRna vaccies? most of the the common cold is two at least of cornoavures along with mers,sars, and h1ni 19 isn't for 19th virus it for the year isn;t it?
This is all good information!
Thank you so much for your explanation, Doc 🙂
Kawasaki H2r disease kills more children than COVID-19.
It seems that the reality of biochemical reactions is complex, to be explained in detail in a few minutes. I am very confused. For example, this video talks about a specific sheddase as a key process
https://www.youtube.com/watch?v=W1k1sUoLPlA
There are scientific articles talking about more than one truncated ACE2 forms, about the process of shedding or cleave catalytically active ACE2 from the cell surface into the extracellular environment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911672/
TMPRSS2 and ADAM17 cleave ace2 differentially and only proteolysis by tmprss2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein
Very interesting and as I have been looking into this , is it fair to say that, regarding the varying amounts of ace2 receptors that different ethnicities have , can this have a bearing on levels of viral intensity seen amongst them? The uk is looking at BAME cases being 42/1000 against 6/1000 in white caucasians. I have read somewhere that levels/amounts of ace2 receptors are far higher in say Asians, north Africans etc. Could there be a link here that the media are ignoring potentially and politically?
I am not a medical person by the way, just a very interested.
electrician.
So Ace2 is the Death Card if you have it in spades.
The human body is amazingly made and even de engineering is very difficult !
This was designed for the ACE receptors , Wuhan did a good job in making it more deadly
I have been creating a series of posts and audio hypnotic inductions pertaining to aspects of COVID-19. My latest post and hypnotic induction focuses intention on membrane function. You can read it here: "COVID-19, Future Visions" at https://www.mindstrengthbalance.com/2020/05/06/covid-19-future-visions/. Comments welcome.
Dr. S, I take eplerenone because I have hyperaldosterone. Can you tell me if that would increase the broken off ace2 like in your diagram?
I'm taking vitamin D3, zinc, vitamin C, and Losartan for high blood pressure. I believe I am blood type O+ because my sister is. I had all flu and pneumonia shots last fall. I have CLL but have not needed treatment yet and I'm 64 year old. I work with people every day. I wear a mask and I am very cautious and use hand sanitizer and other disinfectants. I wash my clothes every day. I disinfect phones remote, knobs, counter tops, and floors frequently. What is my risk?
I had been worried about the effects of my ARB in this pandemic and found this reassuring. Thanks Doc!
Great class! Thank you!
Actually, you are wrong in this case that when Angiotensin 2(AT-II) is high, Ace-2 expression increases. No, when AT-II is high and binds to ATR-1, ACE-2 is internalized and lysed (or degraded) in the cell. So, ACE-2 expression is decreased. But when AT-II is lowered by kidneys, ACE-2 binds to its native binding partner ATR-1. Sars-cov-2 out-compete the ATR-1 for binding to ACE-2. sars-cov-2 and ATR-1 are competing with each other to bind to ACE-2 when there is no AT-II around.
So grateful for all you do!
American College of Cardiology, the American Heart Association, the Heart Failure Society of America, and the European Society of Cardiology—have issued guidelines saying patients should not stop taking the antihypertensive drugs because there’s no evidence to support the claim that they cause more-severe SARS-CoV-2 infections.
In support of that recommendation, Ankit Patel, a clinical and research fellow focusing on the kidneys at Brigham and Women’s Hospital in Boston, and his Brigham colleague Ashish Verma dug into the literature to address the confusion and reported March 24 in JAMA that there’s no definitive evidence to suggest ACE inhibitors and ARBs increase the severity of COVID-19. Another team of doctors, writing in the March 30 issue of the New England Journal of Medicine, came to the same conclusion.
Instead of making COVID-19 symptoms worse, some antihypertensive drugs may actually reduce the severity of infections, and could therefore be used to treat the disease, both sets of doctors say. A closer look at the underlying mechanisms of the medications has also buoyed another idea for how to treat COVID-19—give patients the enzyme ACE2 as a decoy to direct SARS-CoV-2 away from their cells. A biotech company developing such an approach using recombinant ACE2 received regulatory approval today (April 2) to start clinical trials on COVID-19 patients.
I believe research ha since been done in Italy and in NY where most deaths have hypertension as a comorbidity factor median age about 62…it didn’t matter if it was controlled hypertension or not and just slightly more risk for those on Ace or ARB’s. So if you have hypertension and are over 50 ..you/we need better protection!
What about Beta-Blockers like Bystolic?
In lecture 61 you also also said ace-2 receptors exist inside cell walls of veins, arteries. COV-2 binds with these receptors and causes a cascade of symptoms leading to blood clots. Watch the lecture. My question is where are all the ace-2 receptors in the body and can each receptor in every organ they inhabit be affected by the virus binding to it, if those receptors can be exposed to it as it travels through the body ?
Nice research analysis on a most current medical development. The epidemiology and the fact older ppl tend to be over"managed" by pharmacos is only aggravating a sad morbidity of pneumopathy….
I see that these medications increase ACE2, but isn't this the enzyme, and not the receptor?
Really easy!! I have been hearing both sides of the argument and the final truth is actually not difficult it's real simple. The high death rates in Hypertension and Diabetes can be separated by those who are taking ACE2 and ARBS and those who are not taking ACE@ and ARBS. Simple if 2000 people died with COVID19 that had high blood pressure similar age and males and the ARBS and ACE2 death rate was 1500 vs 500 who did not take the medication then you would have an actual number to go off of either way. this could be repeated in China, Italy etc etc
SEEMS TO ME THAT this vlog and that study are a bit backwards… HOW is it that an ARB… ACE-2 Receptor BLOCKER causes MORE ACE-2 receptor cells to form, rather thanbeing BLOCKED.?. Thus, also blocking SARS-CoV-2………………
Great Lecture. Thank you very much
awesome
So can you please answer that question. Why does the Ace-i and ARBs treatment cause ACE-2 expression? It should decrease the ACE-2 expression.
Do the ACE2 receptor and virus spike proteins tangle together like velcro loops and hooks, or are there chemical bonds? What causes the spike binding site to fold out, lower pH?
I stopped taking Lisinopril 40mg daily a week ago when I heard it could worsen the infection. I guess now I should get back on the medication?
Superbe bravo !
So.
Take ace inhibitors, get more infection.
Don't take ace inhibitors, get less infection, but be more susceptible to other health issues
Perfectly engineered virus.
We also know that men are dying 30-40% more from covid than women. And we know that men have more ACE2 receptors than women.
Sounds like more than just a coincidence.
That response from the American Heart Association and others sounds a awful lot like "nothing to see here folks"..
I don't trust the integrity of any study that is essentially protecting Big Pharma and their 200 million customer base worldwide that are taking ace inhibitors.
Many sperm + 1 egg increases chances for pregnancy.
Why wouldn't many corona viruses + one cell increase chances for infection?