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Klotho is an aging-suppressor gene expressed ubiquitously, and its expression is decreased with advancing age, as well as in dialysis and/or aging-related diseases, including CKD and ESRD. The kidney is one of the major organs involved in both dialysis and aging. There is accumulating evidence that Klotho protects renal function. Clinical trials of recombinant human Klotho protein supplementation in patients with CKD and ESRD indicated that Klotho plays an important role in CKD and an increase in serum Klotho level is associated with protection from CKD progression. Recently, Klotho protein has been shown to have protective effects on atherosclerosis, even in healthy individuals, demonstrating its potential anti-aging effect on the heart. In this report, we describe our experience with Klotho expression in solid organ transplantation. Klotho expression was examined on renal transplant biopsies from 29 patients at 1 month after renal transplantation. The Klotho and p-Smad1/5/8 protein expression in transplanted kidneys was higher than in the normal kidney. In contrast, the expression of caveolin-1 protein was decreased in transplanted kidneys. These findings suggest that Klotho may play a protective role in solid organ transplantation.Spontaneous decrease in oxidative stress in rat kidneys after pancreas transplantation: lipid and protein oxidation.
We analyzed the relative protein oxidation in

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Gestational diabetes mellitus (GDM) is one of the commonest diseases in pregnancy. This study estimated the prevalence of GDM in patients attending a primary care unit. The prevalence of glucose tolerance in women attended by the primary care unit of Mataró was determined retrospectively. The study included 4734 pregnant women from the years 1996-1999. According to the criteria of the National Diabetes Data Group, GDM was diagnosed in 9.76% of the cases. The prevalence increased significantly with age, reaching a high of 22.7% in women over 35. GDM was more frequent in multiparous women (12.3%) and in those with a previous history of GDM (19.7%) or diabetic maternal history (14.7%), it was less frequent in women from the university area (8.5%). Oral glucose tolerance test (OGTT) performed in GDM patients detected 3.4% with previous gestational diabetes, while the two following tests were negative in 91.7%. GDM is common in our setting,
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! .. Contabilidad Intermedia De Juan Funes Orellana Pdf Download, Contabilidad Intermedia De Juan Funes Orellana Pdf Download. contabilidad intermedia de juan funes orellana pdfApoptosis of thymocytes induced by chronic inflammatory stimuli is regulated by the Bcl-2-family of cell death regulators.
To further delineate the process of apoptosis, we assessed whether chronic stimuli that lead to T cell apoptosis were dependent on caspases and evaluated the Bcl-2-family of regulators of apoptosis. Chronic stimulation of thymocytes by anti-CD3 and anti-CD28 antibodies, or with superantigen concanavalin A (Con A), augmented apoptosis compared with isotype-matched control antibodies. Using Western blot analysis of caspase-3 expression, we found that the broad-spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk) substantially inhibited apoptosis of thymocytes stimulated with anti-CD3 and anti-CD28