An HACE2 Peptide Mimic Blocks SARS-CoV-2 Pulmonary Cell Infection
In the light of the latest accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central function in cell entry. We designed a collection of peptides mimicking the N-terminal helix of hACE2 protein which contains many of the contacting residues on the binding site (https://technoluddites.org/wiki/index.php/Cytomel_T3_50mcg_-_Weight_Loss_And_Performance_Enhancement) and have a excessive helical folding propensity in aqueous solution. Our greatest peptide mimic binds to the virus spike protein with excessive affinity and is ready to block SARS-CoV-2 human pulmonary cell infection with an inhibitory focus (IC50) in the nanomolar vary. This first in class blocking peptide mimic represents a powerful device that may be utilized in prophylactic and therapeutic approaches to fight the coronavirus disease 2019 (COVID-19).
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Key components in DBulk
