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Selembut Sutera (Eny Arrow) Download Ebook Novel Buku Yogyakarta. A KED. AND SOON YOU WILL FIND OUT!! abdressesuricon4.SHRINKAGE AND FIBROSIS OF RENAL CELLS IN ADULT RAT WITH NEPHROPATHY IS ASSOCIATED WITH OXIDATIVE STRESS.
The most common renal disease in humans is chronic kidney disease (CKD). Oxidative stress is considered as a major factor for the development of CKD and its complications. To evaluate the renal oxidative stress in nephropathy, we measured thiobarbituric acid reactive substance (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) in the kidneys of nephropathy in adult rat. Male Wistar rats were divided into 4 groups and 2 groups were treated with metallothionein inhibitor, thioridazine (20 mg/kg/day for 6 weeks) and folic acid (15 mg/kg/day for 6 weeks) separately. Renal function markers were evaluated by measuring blood urea nitrogen (BUN), serum creatinine (Cr) and serum urea. For histopathological examination, the samples were stained with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). The TBARS, SOD, CAT, GSH and GPx levels in the renal tissue were higher (p = 0.001, p = 0.003, p = 0.04, p = 0.04, p = 0.01, respectively) while the Cr and BUN levels were lower (p = 0.001, p = 0.001) than the control group. In the thioridazine group, the SOD, CAT, GSH and GPx levels were lower (p = 0.001, p = 0.04, p = 0.04, p = 0.01, respectively) while
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